Contract manufacturer of pharmaceutical active ingredients and products, specializing in culture lyophilized probiotics lactic acid bacteria
Med Pharma Service GmbH
BerlinNew on Amplifa
About Med Pharma Service
Med Pharma Service GmbH is a medium-sized, family-owned contract manufacturer based in Berlin. The company offers full-service outsourcing for the healthcare industry: contract manufacturing of medicines, active ingredients, medical devices, and dietary supplements, contract analytical testing, packaging, and pharmaceutical logistics. The core competency for over 50 years has been the production of culture lyophilized probiotics lactic acid bacteria (Lactobacillus, Bifidobacterium) through fermentation and lyophilization; a patented nutrient medium enables the stability of probiotic cultures in liquid suspension. Manufacturing includes mixtures, capsule filling in hard gelatin capsules, packaging in glass vials, fruit cubes, bulkware, as well as primary and secondary packaging according to customer specifications. The internal analytics laboratory tests raw materials and finished products (HPLC/UHPLC, GC, Spectroscopy, microbiological and stability testing according to ICH). Production adheres to GMP; certificates include DIN EN ISO 9001, manufacturing authorization according to §13 AMG, and wholesale authorization according to §52a AMG. Even small batch sizes are accepted.
- Site
- Berlin
- Processes
- Contract manufacturing of pharmaceutical products (Medicines, Active Ingredients, Medical Devices,, Active Ingredient Manufacturing: Fermentation and Lyophilization of Lactic Acid Bacteria, Manufacturing of culture lyophilized microorganisms (Probiotics), Manufacturing of mixtures and capsule products (Filling powders into hard gelatin capsules), Packaging of capsules into glass vials (Primary Packaging), Manufacturing of fruit cubes (Preparation and mixing of a specific dough mass, in cube form), Packaging / Secondary Packaging (Folding carton, label, user information), Bulk production (Culture lyophilized, Hard gelatin capsules, Mixtures of preparations)
- Materials
- Lactic acid bacteria (probiotic active ingredients), Lactobacillus, Bifidobacterium, Hard gelatin (capsules), Glass (vials), Culture Lyophilized Probiotics Lactic Acid Bacteria, Patented Nutrient Medium for Liquid Suspensions, Hard Gelatin Capsules
- Certificates
- DIN EN ISO 9001:2015, Manufacturing Authorization §13 AMG (Human Medicines and Active Ingredients), Wholesale Authorization §52a AMG, GMP Certificate, GDP Certificate, GMP (EU-GMP Guidelines), GDP, DIN EN ISO 13485, Manufacturing Authorization §13 AMG
- Industries
- Pharmaceutical Industry, Dietary Supplements, Medical Devices, Cosmetics, Animal Feed
- 01
Concept and Consulting (Product profile, reports, stability testing plans)
- 02
Active Ingredient Manufacturing: Fermentation and Lyophilization of Lactic Acid
- 03
Manufacturing of Mixtures, Capsule Products, and Fruit Cubes
- 04
Bulk Production
- 05
Packaging (Primary and Secondary Packaging)
- 06
Analytical Quality Control and Release
- 07
Pharmaceutical Logistics: Storage, Picking, Shipping
Raw Materials and Active Ingredients
Culture Lyophilized Probiotics Lactic Acid Bacteria
Active ingredients from Lactobacillus and Bifidobacterium for pharmaceuticals, dietary supplements, and other applications.
Patented Nutrient Medium for Liquid Suspensions
Enables defined shelf life and stability of probiotic cultures in liquid form.
Hard Gelatin Capsules
Filling powder mixtures into capsules of various sizes.
Glass Vials
Primary packaging for packaged capsules.
Location
Berlin
DEProduction, Laboratory, Logistics
- Lot size
- even small batch sizes
- Materials
- Lactic acid bacteria, Lactobacillus, Bifidobacterium, Hard gelatin capsules, powder preparations
- Fermentation
- Lyophilization
- Analytics Laboratory (HPLC/UHPLC, GC, UV-Vis, FT-IR, Karl Fischer)
- Storage and Logistics
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Contract manufacturing of pharmaceutical products (Medicines, Active Ingredients, Medical Devices,Plastic | – | – | – | small batch sizes | Active Ingredients, Lactic Acid Bacteria, Hard Gelatin |
| Active Ingredient Manufacturing: Fermentation and Lyophilization of Lactic Acid BacteriaPlastic | – | – | – | – | Lactic Acid Bacteria, Lactobacillus, Bifidobacterium |
| Manufacturing of culture lyophilized microorganisms (Probiotics)Plastic | – | – | – | – | Lactic Acid Bacteria, Lactobacillus, Bifidobacterium |
| Manufacturing of mixtures and capsule products (Filling powders into hard gelatin capsules)Plastic | – | – | – | – | Powder, Hard Gelatin |
| Packaging of capsules into glass vials (Primary Packaging)Assembly | – | – | – | – | Hard Gelatin, Glass |
| Manufacturing of fruit cubes (Preparation and mixing of a specific dough mass, in cube form)Plastic | – | – | – | – | Dough mass, Fruit |
| Packaging / Secondary Packaging (Folding carton, label, user information)Assembly | – | – | – | – | – |
| Bulk production (Culture lyophilized, Hard gelatin capsules, Mixtures of preparations)Plastic | – | – | – | – | Lactic Acid Bacteria, Hard Gelatin, Preparations |
| Analytics / Contract Analytical Testing (Chemical, physical, instrumental, and microbiological)Testing | – | – | – | – | Active and auxiliary substances, Medicines |
| HPLC/UHPLC Analytics (DAD, UV-Vis & Fluorescence Detector)Testing | – | – | – | – | – |
| GC Analytics (Flame Ionization Detector / FID)Testing | – | – | – | – | – |
| Testing of Active Ingredient Release (Dissolution)Testing | – | – | – | – | – |
| UV-Vis SpectroscopyTesting | – | – | – | – | – |
| FT-IR Spectroscopy (Identity tests)Testing | – | – | – | – | – |
| DC TestsTesting | – | – | – | – | – |
| Pharmaceutical-technical Tests (Hardness, Friability etc.)Testing | – | – | – | – | – |
| Water Determination according to Karl FischerTesting | – | – | – | – | – |
| Microbiological TestingTesting | – | – | – | – | – |
| Stability Studies according to ICH conditions / Ongoing Stability Studies (OGS) / in-use TestsTesting | – | – | – | – | – |
| Pharmaceutical Logistics: Picking, Storage, Shipping (Promotional material shipping, Doctor sampleOther | – | – | – | – | – |
| Concept and Development Support (Product profile, scientific reports,Engineering | – | – | – | – | – |
Additional services
Quality Management
The QM system is based on DIN EN ISO 9001 (certified by DQS Medizinprodukte GmbH) and DIN EN ISO 13485, as well as GMP guidelines (EU-GMP guidelines, AMG, AMWHV, Pharmacopoeias). Regular inspections and audits by customers and the Berlin State Office for Health and Social Affairs accompany operations.
| Evidence | Berlin |
|---|---|
| DIN EN ISO 9001:2015 | |
| GMP (EU-GMP Guidelines) | |
| GDP | |
| DIN EN ISO 13485 | |
| Manufacturing Authorization §13 AMG | |
| Wholesale Authorization §52a AMG |
History
Start of manufacturing culture lyophilized probiotics lactic acid bacteria – according to website over 50 years ago
- 2023
Issuance of manufacturing authorization for human medicines and active ingredients according to §13 AMG (DE_BE_01_MIA_2023-0052-5373-1-MPS-7) and GMP certificates
- 2024
Issuance of authorization for wholesale trade of medicinal products according to §52a AMG (DE_BE_01_WDA_2024-5373-1-MPS-04) and GDP certificate