SEQENS develops and manufactures active ingredients, pharmaceutical intermediates, and specialty ingredients—from R&D to industrial production.
SEQENS
Écully · Porcheville · Roussillon · Aramon · Bourgoin-Jallieu · Nîmes · Lahr (DE) · Billingham (UK) · Middlesbrough (UK) · Devens (US) · Bangpoo (TH) · Neot Hovav (IL) · Pune (IN)New on Amplifa
About SEQENS
SEQENS is an integrated global supplier of solutions and ingredients for the pharmaceutical industry, personal care, and specialty chemicals. The company develops and produces generic and custom APIs, pharmaceutical intermediates, excipients, specialty ingredients, and covers the entire value chain—from raw materials through process development and scale-up to industrial manufacturing. Processes include chemical synthesis (including flow chemistry), biocatalysis, precision fermentation, synthetic biology, and the synthesis of drug-delivery polymers (PLA, PLGA, PEG, PEKK/IMPEKK) and custom lipids. With approximately 3300 employees, 16 production sites, and 9 R&D centers in 9 countries, SEQENS serves over 1500 customers in more than 80 countries, generating a revenue of approx. 1 billion Euros. Customers include Sanofi and UPSA; the German production site Lahr manufactures APIs and pharmaceutical intermediates in GMP and ISO-9001 certified contract manufacturing.
- Site
- Écully, France
- Processes
- Pharmaceutical Synthesis (APIs, Intermediates, Excipients, Custom Synthesis), GMP Production of APIs and Pharmaceutical Intermediates (Lahr), Contract Manufacturing / Tolling (Lahr, Aramon), Acetylsalicylic Acid Manufacturing (Bangpoo, GMP), API Generics Manufacturing (Neot Hovav), Solvent Recovery, Manufacturing of Disinfectants (Hand Sanitizers, NAAHA), Flow Chemistry (Nitration, Fluorination, Chlorination, Cyanation, Hydrogenation,
- Materials
- PEKK (IMPEKK, Kepstan License), PLA, PLGA, PEG (Polyethylene Glycol / Ethylene Oxide Oligomers), Polyhydroxybutyrate, Acrylate Copolymers, Methacrylate Copolymers, Paracetamol
- Certificates
- ISO 9001, GMP (cGMP), ISO 14001, ISO 50001, ISO 45001, EcoVadis Platinum
- Employees
- 3300
- Industries
- Pharmaceutical Industry (APIs, CDMO), Generics, Cosmetics/Personal Care, Flavors & Fragrances, Food & Feed, Agrisciences
- 01
Raw Materials / Fine Chemicals
- 02
Process Development & Scale-up
- 03
Chemical Synthesis / Biocatalysis / Fermentation
- 04
GMP Production of APIs and Intermediates
- 05
Analytics and Quality Control
- 06
Regulatory Affairs and Sales
Products, Polymers, and Processes
PEKK (IMPEKK)
High-performance polymer based on an exclusive Arkema technology license for long-term medical implant applications.
PLA
Drug-Delivery Polymer for galenic applications.
PLGA
Drug-Delivery Polymer for controlled drug release.
PEG (Polyethylene Glycol)
Basis for PEG-lipids and drug-delivery applications.
Paracetamol
Active ingredient with planned 10,000-t production capacity in Roussillon.
Acetylsalicylic Acid
GMP active ingredient production at the Bangpoo site (Thailand).
Salicylic Acid
Produced at the Roussillon site.
D-Serine
Active ingredient produced biocatalytically at multi-ton scale (SEQENZYM AL).
Custom Lipids
Neutral-, PEG-, ionizable, and phospholipid derivatives as well as cholesterol derivatives for drug-delivery systems.
Specialty Enzymes
Natural and optimized enzymes (SEQENZYM) for pharmaceuticals, food, cosmetics, and agrisciences.
Industries
Processes & technical limits
| Processes | Tolerance | Max. part | Weight | Lot size | Materials |
|---|---|---|---|---|---|
| Pharmaceutical Synthesis (APIs, Intermediates, Excipients, Custom Synthesis)Engineering | – | – | – | Gram (kilo lab) – multi-tons | APIs, pharmaceutical intermediates, Excipients |
| GMP Production of APIs and Pharmaceutical Intermediates (Lahr)Engineering | – | – | – | – | APIs, pharmaceutical intermediates |
| Contract Manufacturing / Tolling (Lahr, Aramon)Engineering | – | – | – | – | APIs, pharmaceutical intermediates, Fine Chemicals |
| Acetylsalicylic Acid Manufacturing (Bangpoo, GMP)Engineering | – | – | – | – | Acetylsalicylic acid |
| API Generics Manufacturing (Neot Hovav)Engineering | – | – | – | – | API Generics |
| Solvent RecoveryEngineering | – | – | – | – | Solvents |
| Manufacturing of Disinfectants (Hand Sanitizers, NAAHA)Engineering | – | – | – | up to 100,000 Liters/day | Isopropanol, pharmaceutical quality water, alcohol |
| Flow Chemistry (Nitration, Fluorination, Chlorination, Cyanation, Hydrogenation,Engineering | – | – | – | 50 kg/day (GMP, ton scale); 60 g/h Lab | pharmaceutical fine chemicals |
| Biocatalysis / Biotransformation / BioconversionEngineering | – | – | – | Kg to Tons (GMP) | Enzymes, Pharma Active Ingredients |
| Precision Fermentation and Fermentation (recombinant enzyme production)Engineering | – | – | – | 300 L (Proteus) to 15 m³ (SEQENZYM | Enzymes, Microorganisms, Bacteria, Yeast, Cyanobacteria, Microalgae |
| Synthetic Biology / Genetic and Metabolic Processes (Strain Construction,Engineering | – | – | – | Kg to Tons | Microalgae, Bacteria, Yeast, Metabolites, bioactive peptides, proteins |
| Manufacturing of Specialty Enzymes and Target Ingredients (GMP, non-GMP, non-pharma)Engineering | – | – | – | Kg to Tons | Enzymes, Ingredients |
| Manufacturing of Custom Lipids (Neutral Lipids, PEG-Lipids, cationic/ionizable Lipids,Polymer | – | – | – | Gram – multi-tons | Lipids, PEG-Lipids, Phospholipids, Cholesterol Derivatives |
| Synthesis of Drug-Conjugate Linkers (GMP, kilo lab to multi-ton)Engineering | – | – | – | kilo lab – multi-ton | Linkers, ethylene glycol oligomers, piperazine/piperidine |
| Polymer Synthesis (PLA/PLGA/PEG, PEKK, GMP-Medical-Grade Polymers)Polymer | – | – | – | – | PLA, PLGA, PEG, PEKK (IMPEKK), Polyhydroxybutyrate, (Poly)ester, Acrylate Copolymers, Methacrylate Copolymers |
| Analytics Platform: GMP Testing of APIs and Excipients, Method Development/Validation,Testing | – | – | – | – | APIs, Excipients |
| Solid-State Characterization of APIs (Polymorph Screening, Salt Formation, Co-crystals,Testing | – | – | – | – | APIs, Excipients |
| Formulation and Bioavailability Development (Spray Drying, Hot Melt Extrusion,Engineering | – | – | – | – | APIs, Excipients, Polymers, Lipids |
| Quality Control with FTIR-ATR and Gas Chromatography (Bourgoin-Jallieu)Testing | – | – | – | – | Hand Sanitizer, Alcohol |
| Salicylic Acid Production (Roussillon)Engineering | – | – | – | – | Salicylic acid, Isopropanol |
| PEKK Manufacturing for Long-Term Medical Implant Applications (exclusive Arkema license)Polymer | – | – | – | – | PEKK, IMPEKK |
| Paracetamol Production (planned unit, Roussillon)Engineering | – | – | – | 10,000 t/year (planned) | Paracetamol |
18 Anlagen & Maschinen
| Machine | Manufacturer / model | Quantity | Working area | Year built | Site |
|---|---|---|---|---|---|
| Fermentation Suite | – | 10 (6x1L, | – | – | Nîmes (Proteus) |
| Photobioreactors | – | 2 (9 L) | – | – | Le Bourget du Lac (Alganelle) |
| GMP Flow Chemistry Plant (2 temperature zones, continuous) | – | – | 50 kg/day | – | – |
| Laboratory Flow Chemistry Equipment | – | – | 60 g/h | – | – |
| Kilo-Labs | – | 5 | 1,000 sqm laboratory space | – | Boston'Lab (Devens, USA) |
| Pilot Plant | – | 1 | – | – | Boston'Lab (Devens, USA) |
| cGMP Pilot Plants with Multipurpose Reactors | – | 2 Plants | Total capacity 12 m³ | – | Seqens'Lab (Porcheville, France) |
| XRPD (X-ray Powder Diffractometer) | Malvern-Panalytical Empyrean Series III | – | – | – | – |
| Laser Light Scattering Particle Size Analysis | Malvern Mastersizer 3000 | – | 0.01 µm–3,500 µm | – | – |
| Dynamic Light Scattering | Malvern Zetasizer Pro Red | – | 2–200 nm | – | – |
| Air Classification | Alpine / Hosokawa E200 LS | – | 50–3,500 µm | – | – |
| Morphology-directed Raman Spectroscopy | Malvern-Panalytical Morphology 4-ID | – | – | – | – |
| Surface Analysis (BET) | BELSORP-MINI X / 2S | – | 2–400 nm pore size | – | – |
| Scanning Electron Microscope | Hitachi TM-1000 | – | – | – | – |
| Dynamic Water Vapor Adsorption (DVS) | SMS DVS Intrinsic | – | – | – | – |
| DSC / TGA | Mettler DSC3 / TGA/DSC3+ | – | – | – | – |
| NMR Spectrometer 400 MHz | Bruker Avance III 400 MHz | – | – | – | – |
| High-Throughput Screening (automated platform) | – | – | – | – | Nîmes (Proteus) |
Additional services
Reference customers
Quality and Certifications
The group works with GMP and ISO-9001 certified sites, as well as ISO-14001, ISO-50001, and ISO-45001 certified management systems; most sites are rated Platinum by EcoVadis. Analytics include GMP testing, method development/validation, stability studies (ICH), and modern solid-state characterization (XRPD, DSC/TGA, NMR, Raman, SEM).
| Evidence | Lahr | Roussillon | Bangpoo | Porcheville |
|---|---|---|---|---|
| ISO 9001 | ||||
| GMP (cGMP) | ||||
| ISO 14001 | ||||
| ISO 50001 | ||||
| ISO 45001 | ||||
| EcoVadis Platinum |
History
- 1998
Foundings of Protéus as a pioneer in enzyme optimization.
- 2016
Beginning of the group's EcoVadis rating.
- 2020
COVID Crisis: production of hand disinfectants (up to 100,000 L/day, first French manufacturer); European Care Award 2020.
- 2021
Commissioning of a 1200 m² cGMP quality control lab in Roussillon in the presence of Prime Minister Jean Castex.
- 2023
Planned commissioning of the new Paracetamol production unit (10,000 t/year, approx. €100M investment) in Roussillon; DecarbRON project (approx. €21M) for decarbonization.
- 2024
Exclusive technology license from Arkema for PEKK manufacturing for long-term medical implant applications.
- 2025
Partnership with Brenntag for commercializing non-GMP pharmaceutical intermediates in Europe.
- 2026
Financial restructuring agreed; Wavelength activities disposed of; CELLforCURE seeking buyer for Les Ulis site; EU anti-dumpant investigation into Acetylsalicylic Acid welcomed.